Our research spans from the laboratory to the patient, using the essential tools of molecular and cell biology with new techniques in gene discovery, genetic epidemiology, human and cell imaging technology, cell and gene therapy and clinical research.

 

Heart Disease

We are investigating the use of gene therapy to treat and prevent sudden death from heart rhythm problems. We are looking at ways we can use stem cells to regenerate cardiac muscle damaged by heart attack.

Breast Cancer

We are studying thousands of breast tissue samples to understand the role of the female hormones oestrogen and progesterone in the development of the normal breast and in breast cancer.

 

Multiple Sclerosis

We are studying the interactions between genetic and environmental risk factors that cause auto-immune diseases such as multiple sclerosis.

 

Ovarian Cancer

We are investigating how high grade serious ovarian carcinomas evolve to evade initially effective drug treatment, and ensure patients’ tumours receive molecular testing so their care can be optimised.

 

Mental Health and Neuroscience

We are developing novel brain imaging techniques to help doctors more easily and accurately diagnose and treat mental disorders such as bipolar, ADHD, depression, anxiety and PTSD.

Herpes

We are investigating the application of new techniques used to develop a successful shingles vaccine, to one day vaccinate against the herpes simplex virus.

 
 

Eye Disease

We are researching the mechanisms that cause progressive eye cell death in glaucoma and possible treatments to prevent vision loss using already approved drugs.

Diabetes

We are studying the links between our hormone system, skyrocketing rates of type 2 diabetes and obesity. We are also investigating ways to expand our pioneering type 1 diabetes islet cell transplant program to more patients in Westmead Hospital.

 

Critical Infections

We are looking for better ways to manage deadly hospital infections and investigate novel solutions to antibiotic resistance. We are searching for ways to design new drugs to combat devastating fungal infections.

 

Cell Therapies

We are using human cells to fight infections suffered by bone marrow transplant recipients and are trialling the use of cells engineered to directly target blood cancers.

 

Respiratory Disease

We are researching links between disordered breathing during sleep and diseases such as stroke, melanoma and breast cancer.

HIV

We are developing ways to remove dormant HIV in patients undergoing treatment. We are also looking at how HIV passes through different tissues in the body so we can develop drugs or medical devices to protect people.

 
 

Infectious Diseases

We are researching the complex ways infectious diseases like tuberculosis spread across the world, using new technologies like whole genome sequencing to understand how bacteria mutate in different populations and how drug resistance evolves.

Kidney Disease

We are developing novel brain imaging techniques to help doctors more easily and accurately diagnose and treat mental disorders such as bipolar, ADHD, depression, anxiety and PTSD.

 

Leukaemia

We are investigating ways to disrupt the growth of acute lymphoblastic leukaemia cells and reduce the need for patients to undergo highly toxic chemotherapies.

 

Liver Disease

We are researching the role of genetics and immune response in liver disease to better identify patients at risk of cirrhosis and cancer. We are also researching the biology of viral hepatitis so we can develop new therapies to cure infection and reduce its complications.

 

Melanoma

We are undertaking large-scale genomic analyses of thousands of people from the community, including families with a strong history of melanoma, to find the molecular determinants of risk, progression and treatment response to the disease.