Publications

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2017
  • Doan, T., Graham, J., Clarke, C. (2017). Emerging functional roles of nuclear receptors in breast cancer. Journal of Molecular Endocrinology. 58 (3) , R169-R190. [More Information]

2016
  • Oh, T., Wang, S., Acharya, B., Goode, J., Graham, J., Clarke, C., Yap, A., Muscat, G. (2016). The Nuclear Receptor, ROR(gamma), Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine. 6 , 59-72. [More Information]

2015
  • Bonneterre, J., Hutt, E., Bosq, J., Graham, J., Powell, M., Leblanc, E., Fujiwara, K., Herzog, T., Coleman, R., Clarke, C., et al (2015). Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus. Gynecologic Oncology. 138 (3) , 663-667. [More Information]
  • Hilton, H., Graham, J., Clarke, C. (2015). Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios?. Molecular Endocrinology. 29 (9) , 1230-1242. [More Information]
  • Mote, P., Gompell, A., Howe, C., Hilton, H., Sestak, I., Cuzick, J., Dowsett, M., Hugol, D., Forgez, P., Byth Wilson, K., Graham, J., Clarke, C. (2015). Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial.. Breast Cancer Research and Treatment. 151 (2) , 309-318. [More Information]

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  • Need, E., Selth, L., Trotta, A., Leach, D., Giorgio, L., O’Loughlin, M., Smith, E., Gill, P., Ingman, W., Graham, J., et al (2015). The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype. BMC Cancer. 15 (1) , 1-17. [More Information]

2014
  • Hilton, H., Doan, T., Graham, J., Oakes, S., Silvestri, A., Santucci, N., Kantimm, S., Huschtscha, L., Ormandy, C., Funder, J., Kuczek, E., Clarke, C., et al (2014). Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget. 5 (18) , 8651-8664.
  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PloS One. 9 (2) , 1-12. [More Information]
  • Khushi, M., Clarke, C., Graham, J. (2014). Bioinformatic analysis of cis-regulatory interactions between progesterone and estrogen receptors in breast cancer. PeerJ. 2 , 1-20. [More Information]

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  • Doan, T., Eriksson, N., Graham, J., Funder, J., Simpson, E., Kuczek, E., Clyne, C., Leedman, P., Tilley, W., Fuller, P., Clarke, C., et al (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology. 8 (5) , 998-1013. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment. 143 (3) , 423-433.
  • Hilton, H., Graham, J. (2014). The molecular landscape of the normal human breast- defining normal. Breast Cancer Research. 16 (3) , 1-3. [More Information]

2013
  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology. 28 (9) , 1197-1204.
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment. 142 (1) , 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology. 8 (1) , 1-7. [More Information]

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  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.. Pathology. 45 (7) , 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology. 27 (2) , 350-365. [More Information]

2012
  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. Translational Endocrinology & Metabolism: Breast Cancer Update. , 1-28.
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PloS One. 7 (4) , 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology. 357 (1/2) , 1-3. [More Information]

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  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology. 361 (1-2) , 191-201. [More Information]

2010
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology. 24 (7) , 1380-1392. [More Information]

2009
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology. 150 (7) , 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia. 14 (4) , 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal. 23 (2) , 546-556. [More Information]

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  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling. 7 , 1-13.

2007
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop. 0 (1) , 77-107.

2006
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity.. Molecular Endocrinology. 21 (1) , 14-29.
  • Chadli, A., Graham, J., Abel, M., Jackson, T., Gordon, D., Wood, W., Felts, S., Horwitz, K., Toft, D. (2006). GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Molecular and Cellular Biology. 26 (5) , 1722-1730. [More Information]
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.. Oncogene. 25 (58) , 7597-7607.

2005
  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells.. Molecular Endocrinology. 19 (11) , 2713-2735.

2003
  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology. 31 (2) , 241-253.

2002
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research. 4 (5) , 187-190.