Publications

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  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell (Nankievell), B., O'Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology. 83 (4) , A23-A24.

  • Hawthorne, W., Cachia, A., Walters, S., Patel, A., Clarke, J., O'Connell, P., Chapman, J., Allen, R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation. 9 , 867-875.

  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., et al (2013). A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis. Cell Transplantation. 22 (11) , 2147-2159.

  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes. 61 (5) , 1180-1191.

  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., et al (2013). Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation. 20 (2) , 100-109.

  • Lehnert, A., Hawthorne, W., O'Connell, P., Mottram, P., Han, W., Walters, S., Patel, A., Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology. 9 , 51-56.

  • Guo, F., Xing, X., Hawthorne, W. J., Dong, Q., Ye, B., Zhang, J., Liang, Q., Nie, W. and Wang, W. (2014). Characterization of PERV in a new conserved pig herd as potential donor animals for xenotransplantation in China. Virology Journal. (11)

  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. (2005). Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation. 12 (4) , 303-307.

  • Liuwantara, D., Chew, Y., Favaloro, E., Hawkes, J., Burns, H., O'Connell, P., Hawthorne, W. (2016). Characterizing the mechanistic pathways of the instant blood-mediated inflammatory reaction in xenogeneic neonatal islet cell transplantation. Transplantation Direct. 2 (6) , 1-10.

  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation. 14 (1) , 48-59.

  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell (Nankievell), B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial.. Medical Journal of Australia. 184 (5) , 221-225.

  • Stewart, J., Tarantal, A., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., D'Apice, A., Cowan, P., Kearns-Jonker, M. (2015). Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models. Xenotransplantation. 22 (6) , 413-426.

  • Hawthorne, W., Salvaris, E., Phillips, P., Hawkes, J., Liuwantara, D., Burns, H., Barlow, H., Stewart, A., Peirce, S., Hu, M., O'Connell, P., et al (2014). Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons. American Journal of Transplantation. 14 (6) , 1300-1309.

  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. 84 (3) , A16-A16.

  • Hawthorne, W., Patel, A., O'Hara, J., Akima, S., Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P., O'Connell, P. (2006). Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006). 84 , A1-A1.

  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation. 97 (1) , 30-38.

  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. (2007). Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation. 14 (2) , 119-125.

  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., et al (2012). Expression of Pro- and Anti-apoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation. Cell Transplantation. 21 (1) , 49-60.

  • O'Connell, P., Hawthorne, W., Simond, D., Chapman, J., Chen, Y., Patel, A., Walters, S., Burgess, J., Weston, L., Stokes, R., Moran, C., Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation. 12 (4) , 308-315.

  • Feller, J., Simpson, A., Nelson, M., O'Connell, P., Swan, M., Hawthorne, W., Tao, C., O'Brien, B. (2008). Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. Journal of Clinical Endocrinology and Metabolism. 93 (9) , 3560-3567.

  • Joglekar, M., Trivedi, P., Kay, T., Hawthorne, W., O'Connell, P., Jenkins, A., Hardikar, A., Thomas, H. (2016). Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. Apoptosis. 21 (4) , 379-389.

  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation. 21 (9) , 2063-2078.

  • Kim, H., Hawthorne, W. J., Kang, H. J., Lee, Y. J., Hwang, J.-I., Hurh, S., Ro, H., Jeong, J. C., Cho, B., Yang, J. and Ahn, C. (2015). Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno-immune response. Xenotransplantation. 4 (22) , 260-272.

  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Biankin, A., Kench, J., Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical Investigation. 120 (6) , 2171-2183.

  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Gunton, J., et al (2013). Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation. 22 (2) , 253-266.

  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation. 85 (12) , 1841-1848.

  • Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond, D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation. 86 (6) , 865-874.

  • Horton, P., Hawthorne, W., Walters, S., Patel, A., O'Connell, P., Chapman, J., Allen, R. (2000). Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation. 9 , 877-887.

  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation. 13 , 2819-2830.

  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation. 80 (10) , 1468-1475.

  • Marathe, C., Drogemuller, C., Marathe, J., Loudavaris, T., Hawthorne, W., O'Connell, P., Radford, T., Kay, T., Horowitz, M., Coates, P., et al (2015). Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients. Hormone And Metabolic Research. 47 (1) , 16-23.

  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation. 11 (2) , 174-179.

  • Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A., O'Connell, P., Hawthorne, W. (2006). Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006). 84 , A8-A9.

  • Jimenez, E., Davies, S., Phillips, P., O'Connell, P., Hawthorne, W. (2015). Long-term cultured neonatal islet cell clusters demonstrate better outcomes for reversal of diabetes: In vivo and molecular profiles. Xenotransplantation. 22 (2) , 114-123.

  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., et al (2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.. Cell. 122 (3) , 337-349.

  • O'Connell, P., Holmes-Walker, J., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., et al (2013). Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation. 13 (7) , 1850-1858.

  • Wong, M. S., Tso, A., Ali, M., Hawthorne, W. J. and Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism. 3 (40) , 229-234.

  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation.. Xenotransplantation. 16 (1) , 45-46.

  • Allen, R., Nankivell (Nankievell), B., Hawthorne, W., O'Connell, P., Chapman, J. (2001). Pancreas and islet transplantation: an unfinished journey. Transplantation Proceedings. 33 , 3485-3488.

  • Tran, H., Turingan, I., Tran, K., Zajkowska, M., Lam, V. and Hawthorne, W. (2014). Potential benefits of single-port compared to multiport laparoscopic inguinal herniorraphy: a prospective randomized controlled study. Hernia. 12 (3) , e29-e29.

  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation. 18 (6) , 390-399.

  • Brady, J., Harrison, L., Goodman, D., Cowan, P., Hawthorne, W., O'Connell, P., Sutherland, R., Lew, A. (2014). Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. Clinical & Translational Immunology. 3 (12) , 1-7.

  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. (2006). Real-time PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006). 84 , A24-A24.

  • Chung, H., Lam, V., Yuen, L., Ryan, B., O'Connell, P., Chapman, J., Hawthorne, W., Pleass, H. (2015). Renal transplantation: better fat than thin. Journal of Surgical Research. 194 (2) , 644-652.

  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation. 83 (5) , 615-623.

  • Stewart, J., Tarantal, A., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., D'Apice, A., Cowan, P., Kearns-Jonker, M. (2014). Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets. Xenotransplantation. 21 (4) , 341-352.

  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation. 22 (10) , 1929-1941.

  • Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation. 15 (5) , 307-312.

  • Tran, H., Tran, K., Turingan, I., Zajkowska, M., Lam, V. and Hawthorne, W. (2015). Single-incision laparoscopic inguinal herniorraphy with telescopic extraperitoneal dissection: technical aspects and potential benefits. Hernia. 3 (19) , 407-416.

  • Hanh Minh, T., Kim, T., Zajkowska, M., Lam, V. and Hawthorne, W. (2014). Single-Incision Laparoscopic Intraperitoneal Onlay Mesh Repair for the Treatment of Multiple Recurrent Inguinal Hernias. Jsls-Journal of the Society of Laparoendoscopic Surgeons. 3 (35) , 469-+.

  • Tran, H., Tran, K., Zajkowska, M., Lam, V. and Hawthorne, W. J. (2015). Single-Incision Laparoscopic Repair of Spigelian Hernia. Jsls-Journal of the Society of Laparoendoscopic Surgeons. 1 (19)

  • Tran, H., Tran, K., Zajkowska, M., Lam, V. and Hawthorne, W. J. (2015). Single-port onlay mesh repair of recurrent inguinal hernias after failed anterior and laparoscopic repairs. JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons. 1 (19) , e2014.00212-e2014.00212.

  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation. 91 (5) , 515-521.

  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. The Journal of Immunology. 170 (5) , 2750-2758.

  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'Connell, P. (2011). The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation. 91 (8) , 841-846.

  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, M., Chapman, J., O'Connell, P. (2009). Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal Of Transplantation. 9 , 1533-1540.

  • Horton, P., Hawthorne, W., Walters, S., Patel, T., Stewart, G., Allen, R., Chapman, J. (2008). Tolerance Induction in a Large-Animal Model Using Total Lymphoid Irradiation and Intrathymic Bone Marrow. Transplantation. 86 (12) , 1830-1836.

  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet?. Current Diabetes Reports. 13 (5) , 687-694.

  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. (2006). Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006). 84 , A8-A8.

  • Chen, Y., Stewart, J., Gunthart, M., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., d'Apice, A., Cowan, P., Kearns-Jonker, M. (2014). Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation. 21 (3) , 244-253.