PhD or Masters
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic kidney disease in adults characterised by the formation of kidney cysts. It caused by mutations in either of the polycystic kidney disease genes (PKD1 or PKD2) genes which in turn encode the proteins, polycystin-1 and polycystin-2. Presently, renal ultrasound is the mainstay of making the diagnosis of ADPKD but a simple proteogenomic assay would be very useful in clinical practice. The aim of this project is to integrate the genomic and proteomic characteristics of ADPKD as part of a clinical trial, with the goal of developing an assay that might be useful for clinical practice.
Supervisor: A/Prof. Gopala Rangan, email@example.com