12-Nov-15

PhD or Masters or Honours

Immuno-metabolism is a new field of research that deals with the metabolism of immune cells in response to inflammatory stimuli. Activated immune cells are glucose avid and have a metabolism similar to that of cancer cells. Nanoparticles are readily taken up by liver. In this project we use nanoparticles loaded with 2-deoxyglucose (inhibits glucose usage) which are attached to antibodies. We use this cargo delivery system to target immune cells to modulate glucose consumption by the immune cells. We then investigate the consequences on liver immune homeostasis and inflammation.

Supervisor: Prof. Jacob George, jacob.george@sydney.edu.au