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Publications

Dr Leighton ClancyCo-scientific Director - BMT Cell Therapies
612 8890 9873

Related Links

BMT Cell Therapies, Cancer

Academic Qualifications

BSc (Hons Class I), PhD

Publications

  1. Castellano-González G, McGuire HM, Luciani F, Clancy LE, Li Z, Avdic S, Hughes B, Singh M, Fazekas de St Groth B, Renga G, Pariano M, Bellet MM, Romani L, Gottlieb DJ. Rapidly expanded partially HLA DRB1-matched fungus-specific T cells mediate in vitro and in vivo antifungal activity. Blood Advances 2020; 4(14):3443-3456.
  2. McGuire HM, Rizzetto S, Withers BP, Clancy LE, Avdic S, Stern L, Patrick E, Fazekas de St Groth B, Slobedman B, Gottlieb DJ, Luciani F, Blyth E. Mass cytometry reveals immune signatures associated with cytomegalovirus (CMV) control in recipients of allogeneic haemopoietic stem cell transplant and CMV-specific T cells. Clinical Translational Immunology 2020;9(7):e1149.
  3. Jiang W, Withers B, Sutrave G, Clancy LE, Yong MI, Blyth E. Pathogen-Specific T Cells Beyond CMV, EBV and Adenovirus. Current Hematologic Malignancy Reports 2019;4:247-260.
  4. Withers B, Clancy L, Burgess J, Simms R, Brown R, Micklethwaite K, Blyth E, Gottlieb D.  Establishment and operation of a third party virus-specific T-cell bank within an allogeneic stem cell transplant program. Biol Blood Marrow Transplant 2018;4(12):2433-2442. 
  5. Kliman D, Castellano-Gonzalez G, Withers B, Street J, Tegg E, Mirochnik O, Lai J, Clancy L, Gottlieb D, Blyth E. Ultra-Sensitive Droplet Digital PCR for the Assessment of Microchimerism in Cellular Therapies. Biol Blood Marrow Transplant 2018; 24(5):1069-1078.
  6. Castellano-Gonzalez G, Clancy L, Gottlieb DJ. Prospects for adoptive T-cell therapy for invasive fungal disease. Current Opinion Infectious Diseases 2017; 30(6):518-527.
  7. Ma CKK, Clancy L, Deo S, Blyth E, Micklethwaite KP and Gottlieb DJ. Adjuvant peptide pulsed dendritic cell vaccination in addition to T cell adoptive immunotherapy for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Biology of Blood and Marrow Transplantation 2018; 24(1):71-77.
  8. Withers B, Blyth B, Clancy L, Yong A, Fraser C, Burgess J, Simms R, Castellano-Gonzalez G, Kliman D, Dubosq M-C, Bishop D, Sutrave G, Ma CKM, Shaw P, Micklethwaite K and Gottlieb D. 3rd-party virus specific T-cells for CMV infection post-HSCT mediate durable viral control by driving transplant donor CD8 T cell recovery. Blood advances 2017;1:2193-2205.
  9. Ma CK, Clancy L, Deo S, Blyth E, Micklethwaite KP, Gottlieb DJ. Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy. Cytotherapy 2017;19(1):107-118. 
  10. Blyth E, Withers B, Clancy L, Gottlieb D. CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence. 2016 Aug 9:1-14.
  11. Deo, SS, Virassamy B, Halliday C, Clancy L, Chen S, Meyer W, Sorrell TC, Gottlieb DJ. Stimulation with lysates of Aspergillus Terreus, Candida krusei and Rhizopus oryzae maximizes cross-reactivity of anti-fungal T cells. Cytotherapy 2016; 18 (1): 65-79.
  12. Ramanayake S, Bilmon I, Bishop D, Dubosq MC, Blyth E, Clancy L, Gottlieb D, Micklethwaite K. Low-cost generation of Good Manufacturing Practice-grade CD19-specific chimeric antigen receptor-expressing T cells using piggyBac gene transfer and patient-derived materials. Cytotherapy 2015; 17(9):1251-67.
  13. Ma CK, Blyth E, Clancy L, Simms R, Burgess J, Brown R, Deo S, Micklethwaite KP, Gottlieb DJ. Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. Cytotherapy 2015;17(10):1406-20.
  14. Macesic N, Langsford D, Nicholls K, Hughes P, Gottlieb DJ , Clancy L, Blyth E, Micklethwaite K, Withers B, Majumdar S, Fleming S, Sasadeusz J. Adoptive T-cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.  American Journal of Transplantation 2015;15(3):827-32.
  15. Blyth E, Clancy L and Gottlieb D.  Moving towards virus-specific T cells post-stem cell transplant as standard of care. ISBT Science Series 2015; 10(51):349-356.
  16. Blyth E, Clancy L, Simms R, et al. Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood 2013;121:3745-58.
  17. Clancy LE, Blyth E, Simms RM, et al. Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biol Blood Marrow Transplant 2013;19:725-34.
  18. Avdic S, Cao JZ, McSharry BP, Clancy LE, Brown R, Steain M, Gottlieb DJ, Abendroth A, Slobedman B. Human cytomegalovirus interleukin-10 polarizes monocytes toward a deactivated M2c phenotype to repress host immune responses. J Virol 2013 Sep;87(18):10273-82.
  19. Gaundar SS, Clancy L, Blyth E, Meyer W, Gottlieb DJ. Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus. Cytotherapy 2012;14:1119-30.
  20. Gaundar SS, Blyth E, Clancy L, Simms RM, Ma CK, Gottlieb DJ. In vitro generation of influenza-specific polyfunctional CD4+ T cells suitable for adoptive immunotherapy. Cytotherapy 2012;14:182-93.
  21. Blyth E, Gaundar SS, Clancy L, et al. Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy 2012;14:724-32.
  22. Blyth E, Clancy L, Simms R, et al. BK virus-specific T cells for use in cellular therapy show specificity to multiple antigens and polyfunctional cytokine responses. Transplantation 2011;92:1077-84.
  23. Micklethwaite KP, Clancy L, Sandher U, et al. Prophylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation. Blood 2008;112:3974-81.
  24. Jones LA, Clancy LE, Rawlinson WD, White PA. High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity. Antimicrob Agents Chemother 2006;50:3019-27.
  25. Clancy LE, Craig ME, White PA, Rawlinson WD. Human enterovirus isolates from an outbreak typed using heteroduplex mobility analysis. J Med Virol 2005;76:215-22.
  26. Bull RA, Hansman GS, Clancy LE, Tanaka MM, Rawlinson WD, White PA. Norovirus recombination in ORF1/ORF2 overlap. Emerg Infect Dis 2005;11:1079-85.