PhD, Masters, Honours
To date, most studies of genetic variation between individuals that contribute to tissue scarring and to cancer have focused on single nucleotide polymorphisms (SNPs), the most common type of genetic variation. However, SNPs explain only a small percentage of the heritability of complex diseases (4), explaining ~20% of heritability. This suggests that other variants and types of genetic variation remain to be discovered. Epigenetics is likely a major player in defining missing heritability, but the precise details are yet to be dissected. In this project, we will investigate the role of epigenetics in tissue scarring/fibrosis. The project will involve working with human samples.
Supervisor: Dr. Mohammed Eslam mohammed.eslam@sydney.edu.au