Our research aims to improve the health and wellbeing of people with a range of chronic problems such as diabetes, obesity, liver disease and loss of muscle strength.

We study hormones, using a range of new models from cell culture through to human clinical studies to understand the processes underlying disease and find ways of preventing and treating these increasingly common conditions.

Diseases we research

  • Diabetes

  • Obesity

  • Liver diseases

  • Loss of muscle strength function

Our research themes:

Our diabetes research focuses on the biology of beta-cells – the cells in the pancreas that produce insulin – and the islets where they live. We study islet transplantation, beta-cell survival and beta-cell function – with a particular focus on ARNT and HIF-1a.

Another theme of our research is the role of vitamin D deficiency in liver disease. We are studying how vitamin D affects progression of cirrhosis and liver fibrosis, the regeneration of the liver after injury, and survival of liver cells after liver toxins.

We are also studying adipose tissue (different types of fat tissue) and its role in obesity and the metabolic consequences that it entails.