Ludwig Engel Centre for Respiratory Research
We combine both laboratory research and clinical studies aimed at identifying the pathophysiological basis of respiratory and sleep disorders.
We have a very active clinical trials program and have been involved in many trials testing new clinical treatments across a spectrum of respiratory disorders.
Cystic fibrosis is the most common inherited disorder in Australia, and is caused by mutations on the CFTR gene. Dysfunction of CFTR affects ion and fluid transport in the lungs, liver, gut and pancreas.
In collaboration with the Cancer Research Centre, we have started by investigating endometrial cancer, breast cancer and melanoma. We are comparing data on patients’ tumours with information on their sleep to understand how obstructive sleep apnoea and other sleep disorders may affect cancer biology.
We study the physiology of the upper airway to understand the conditions under which it narrows and collapses, resulting in sleep disordered breathing. Our research focuses on the mechanical properties of the tissues of the upper airway and why they fail in obstructive sleep apnoea
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