Publications

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2019
  • Wallington-Beddoe, C., Xie, V., Tong, D., Powell, J., Lewis, A., Davies, L., Pitson, S., Bradstock, K., Bendall, L. (2019). Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia. British Journal of Haematology. 184 (3) , 440-483. [More Information]

2018
  • Xie, V., Tong, D., Wallington-Beddoe, C., Bradstock, K., Bendall, L. (2018). Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. Biomarker Research. 6 , 1-7. [More Information]
  • Xie, V., Tong, D., Wallington-Beddoe, C., Bradstock, K., Bendall, L. (2018). Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. Biomarker Research. 6 (1) , 1-7. [More Information]

2017
  • Shahin, K., Mattar, Z., Silveira, P., Hsu, W., Bendall, L., Hart, D., Bradstock, K. (2017). Bone Marrow Graft-Versus-Host Disease in Major Histocompatibility Complex-Matched Murine Reduced-Intensity Allogeneic Hemopoietic Cell Transplantation. American Journal Of Transplantation. 101 (11) , 2695-2704. [More Information]
  • Bendall, L. (2017). Extracellular molecules in hematopoietic stem cell mobilisation. International Journal of Hematology. 105 (2) , 118-128. [More Information]
  • Basnett, J., Xie, V., Cisterne, A., Bradstock, K., Bendall, L. (2017). Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. PloS One. 12 (11) , 1-7. [More Information]

2015
  • Daver, N., Boumber, Y., Kantarjian, H., Ravandi, F., Cortes, J., Rytting, M., Kawedia, J., Basnett, J., Culotta, K., Zeng, Z., Bendall, L., et al (2015). A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia. Clinical Cancer Research. 21 (12) , 2704-2714. [More Information]
  • Welschinger, R., Bendall, L. (2015). Temporal tracking of cell cycle progression using flow cytometry without the need for synchronization. Journal of Visualized Experiments. 2015 (102) , 1-10. [More Information]

2014
  • Bendall, L., Green, D. (2014). Autopsy of a cell. Leukemia. 28 (6) , 1341-1343. [More Information]
  • Wong, J., Welschinger, R., Hewson, J., Bradstock, K., Bendall, L. (2014). Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia. Oncotarget. 5 (21) , 10460-10472.
  • Bendall, L., Bradstock, K. (2014). G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent. Cytokine & Growth Factor Reviews. 25 (4) , 355-367. [More Information]

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  • Baraz, R., Cisterne, A., Saunders, P., Hewson, J., Thien, M., Weiss, J., Basnett, J., Bradstock, K., Bendall, L. (2014). mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death. PloS One. 9 (7) , 1-10. [More Information]
  • Cisterne, A., Baraz, R., Khan, N., Welschinger, R., Basnett, J., Fung, C., Rizos, H., Bradstock, K., Bendall, L. (2014). Silencer of death domains controls cell death through tumour necrosis factor-receptor 1 and caspase-10 in acute lymphoblastic leukemia. PloS One. 9 (7) , 1-10. [More Information]
  • Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., Bendall, L. (2014). Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression. Cancer Research. 74 (10) , 2803-2815. [More Information]

2013
  • Winkler, I., Bendall, L., Forristal, C., Helwani, F., Nowlan, B., Barbier, V., Shen, Y., Cisterne, A., Sedger, L., Levesque, J. (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica. 98 (3) , 325-333. [More Information]
  • Wallington-Beddoe, C., Bradstock, K., Bendall, L. (2013). Oncogenic properties of sphingosine kinases in haematological malignancies. British Journal of Haematology. 161 (5) , 623-638. [More Information]
  • Welschinger, R., Liedtke, F., Basnett, J., Dela Pena, A., Juarez, J., Bradstock, K., Bendall, L. (2013). Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice. Experimental Hematology. 41 (3) , 293-302.e1. [More Information]

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  • Saunders, P., Weiss, J., Welschinger, R., Baraz, R., Bradstock, K., Bendall, L. (2013). RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine. Oncogene. 32 (40) , 4789-4797. [More Information]
  • Bendall, L., Basnett, J. (2013). Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. Current Opinion In Hematology. 20 (4) , 281-288. [More Information]

2012
  • Harun, N., Bradstock, K., Bendall, L. (2012). Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors. Novel Developments in Stem Cell Mobilization. , 37-54.
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PloS One. 7 (5) , 1-7. [More Information]
  • Klionsky, D., Abdalla, F., Abeliovich, H., Abraham, R., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J., Bendall, L., Feng, C., Sidhu, S., Xia, P., et al (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8 (4) , 445-544. [More Information]

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  • Winkler, I., Pettit, A., Raggatt, L., Jacobsen, R., Forristal, C., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L., Sims, N., et al (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia. 26 (7) , 1594-1601. [More Information]
  • Khan, N., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2012). Para-NO-aspirin inhibits NF-kB and induces apoptosis in B-cell progenitor acute lymphoblastic leukemia. Experimental Hematology. 40 (3) , 207-215.e1. [More Information]
  • Juarez, J., Harun, N., Thien, M., Welschinger, R., Baraz, R., Dela Pena, A., Pitson, S., Rettig, M., DiPersio, J., Bradstock, K., Bendall, L. (2012). Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood. 119 (3) , 707-716. [More Information]

2011
  • Wallington-Beddoe, C., Hewson, J., Bradstock, K., Bendall, L. (2011). FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy. 7 (7) , 707-715. [More Information]
  • Bendall, L. (2011). It's all in the timing. Blood. 118 (23) , 5983-5984. [More Information]
  • To, L., Levesque, J., Herbert, K., Winkler, I., Bendall, L., Hiwase, D., Antonenas, V., Rice, A., Gottlieb, D., Mills, A., Rasko, J., et al (2011). Mobilisation strategies for normal and malignant cells. Pathology. 43 (6) , 547-565. [More Information]

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  • Saunders, P., Cisterne, A., Weiss, J., Bradstock, K., Bendall, L. (2011). The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia. Haematologica. 96 (1) , 69-77. [More Information]
  • Wei, J., Yee, C., Ramanathan, P., Bendall, L., Williamson, P. (2011). Variation in Immunophenotype of Lactating Mice. American Journal of Reproductive Immunology. 89 , 178-184. [More Information]

2010
  • Sedger, L., Katewa, A., Petterson, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010). Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood. 115 (16) , 3258-3268. [More Information]
  • Bendall, L. (2010). New and Emerging Drug Targets for the Treatment of Hematological Malignancies.. Current Drug Targets. 11 (7) , 767-8.
  • Deo, S., Bendall, L. (2010). The Potential and Limitations of p38MAPK as a Drug Target for the Treatment of Hematological Malignancies. Current Drug Targets. 11 (7) , 823-833. [More Information]

2009
  • Juarez, J., Thien, M., Dela Pena, A., Baraz, R., Bradstock, K., Bendall, L. (2009). CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK. British Journal of Haematology. 145 , 491-499. [More Information]
  • Crazzolara, R., Bendall, L. (2009). Emerging treatments in acute lymphoblastic leukemia. Current Cancer Drug Targets. 9 (1) , 19-31. [More Information]
  • Deo, S., Bradstock, K., Bendall, L. (2009). p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells. Cell Cycle. 8 (18) , 2977-2985.

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  • Crazzolara, R., Cisterne, A., Thien, M., Hewson, J., Baraz, R., Bradstock, K., Bendall, L. (2009). Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood. 113 (14) , 3297-3306. [More Information]
  • Crazzolara, R., Bradstock, K., Bendall, L. (2009). RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy. 5 (5) , 727-728. [More Information]
  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling. 21 (2) , 339-348. [More Information]

2008
  • Khan, N., Cisterne, A., Devidas, M., Shuster, J., Hunger, S., Shaw, P., Bradstock, K., Bendall, L. (2008). Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor acute lymphoblastic leukemia lacking adverse or favorable genetics. Leukemia and Lymphoma. 49 (4) , 710-718. [More Information]

2007
  • Khan, N., Bradstock, K., Bendall, L. (2007). Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. British Journal of Haematology. 138 (3) , 338-348.
  • Juarez, J., Dela Pena, A., Baraz, R., Hewson, J., Khoo, M., Cisterne, A., Fricker, S., Fujii, N., Bradstock, K., Bendall, L. (2007). CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. Leukemia. 21 (6) , 1249-1257.
  • Juarez, J., Baraz, R., Deo, S., Bradstock, K., Bendall, L. (2007). Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. Haematologica. 92 (4) , 450-459.

2006
  • Belov, L., Mulligan, S., Barber, N., Woolfson, A., Scott, M., Stoner, K., Chrisp, J., Sewell, W., Bradstock, K., Bendall, L., Sartor, M., Young, G., Wiley, J., Christopherson, R., et al (2006). Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray.. British Journal of Haematology. 135 (2) , 184-97.
  • Christopherson, R., Stoner, K., Barber, N., Belov, L., Woolfson, A., Scott, M., Bendall, L., Mulligan, S. (2006). Classification of AML using a monoclonal antibody microarray. Methods in molecular medicine. 125 , 241-251.
  • Khan, N., Bendall, L. (2006). Role of WNT signaling in normal and malignant hematopoiesis.. Histology and histopathology. 21 (7) , 761-774.

2005
  • Sedger, L., Bendall, L., Gottlieb, D., Alexander, S., Osvath, S. (2005). A novel mechanism of viral subversion of TNF-R signalling by the poxvirus TNF-R like protein, T2. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005. 66 , 537-538.
  • Bendall, L. (2005). Chemokines and their receptors in disease.. Histology and histopathology. 20 (3) , 907-926.
  • Juarez, J., Hewson, J., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2005). CXCR4 antagonists mobilize acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment in mice. 47th Annual Meeting of the American Society of Hematology (ASH). 106 , 227B-227B.

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  • Bendall, L., Baraz, R., Juarez, J., Shen, W., Bradstock, K. (2005). Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Research.
  • Campana, D., Iwamoto, D., Bendall, L., Bradstock, K. (2005). Growth requirements and immunophenotype of acute lymphoblastic leukemia progenitors. Blood. 105 (10) , 4150.
  • Sloane, A., Raso, V., Dimitrov, D., Xiao, X., Deo, S., Muljadi, N., Restuccia, D., Turville, S., Kearney, C., Broder, C., Zoellner, H., Cunningham, A., Bendall, L., Lynch, G. (2005). Marked structural and functional heterogeneity in CXCR4: Separation of HIV-1 and SDF-1 alpha responses. Immunology and Cell Biology. 83 (2) , 129-143.
  • Bendall, L., Bradstock, K. (2005). New therapies targeting chemokine receptors: Can changing the way cells traffic be used to treat human disease?. Current Topics in Membranes. 55 , 331-365.
  • Nilsson, S., Johnston, H., Whitty, G., Williams, B., Webb, R., Denhardt, D., Bertoncello, I., Bendall, L., Simmons, P., Haylock, D. (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood. 106 (4) , 1232-1239.
  • Shaw, S., Haylock, D., Lock, R., Bendall, L., Simmons, P., Johnston, H., Fletcher, K., Webb, R., Brown, T., Liem, N., et al (2005). The role of hyaluronic acid in normal and perturbed hemopoietic stem cell biology. Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. 1 , 293-299.
  • Khan, N., Bradstock, K., Bendall, L. (2005). The Wnt/beta-catenin pathway promotes growth and survival of acute lymphoblastic leukaemia (ALL) cells in vitro. 47th Annual Meeting of the American Society of Hematology (ASH). 106 , 217B-217B.

2004
  • Juarez, J., Bendall, L., Bradstock, K. (2004). Chemokines And Their Receptors As Therapeutic Targets: The Role Of The Sdf-1/Cxcr4 Axis.. Current Pharmaceutical Design. 10 (11) , 1245-1259.
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts.. Breast Cancer Research and Treatment. 83 (3) , 211-220.
  • Bendall, L., Nilsson, S., Khan, N., James, A., Bonnet, C., Lock, R., Papa, R., Bradstock, K., Gottlieb, D. (2004). Role of CD44 variant exon 6 in acute lymphoblastic leukaemia: association with altered bone marrow localisation and increased tumor burden. Leukemia. 18 (7) , 1308-1311.

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  • Juarez, J., Bendall, L. (2004). SDF-1 And CXCR4 In Normal And Malignant Hematopoiesis.. Histology and histopathology. 19 (1) , 299-309.

2003
  • Bendall, L., James, A., Zannettino, A., Simmons, P., Gottlieb, D., Bradstock, K. (2003). A novel CD44 antibody identifies an epitope that is aberrantly expressed on acute lymphoblastic leukaemia cells. Immunology and Cell Biology. 81 (4) , 311-319.
  • Lévesque, J., Hendy, J., Takamatsu, Y., Simmons, P., Bendall, L. (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. Journal of Clinical Investigation. 111 (2) , 187-196.
  • Juarez, J., Gottlieb, D., Bradstock, K., Bendall, L. (2003). Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia. 17 (7) , 1294-1300.

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  • Zannettino, A., Roubelakis, M., Welldon, K., Jackson, D., Simmons, P., Bendall, L., Henniker, A., Harrison, K., Niutta, S., Bradstock, K., et al (2003). Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Biochemical Journal. 370 (2) , 537-549.

2002
  • Saad, S., Gottlieb, D., Bradstock, K., Overall, C., Bendall, L. (2002). Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Cancer Research. 62 , 283-289.

2001
  • McQibban,, G., Butler,, G., Gong,, J., Bendall, L., Power, C., Clark-Lewis, I., Overall, M. (2001). Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. Journal of Biological Chemistry. 276 (47) , 43503-43508.
  • Shen, W., Bendall, L., Gottlieb, D., Bradstock, K. (2001). The chemokine receptor CXCR4 enhances integrin mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. Experimental Hematology. 29 (12) , 1439-1447.

2000
  • Bendall, L., Bradstock, K., Gottlieb, D. (2000). Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34+ cells. Leukemia. 14 (7) , 1239-1246.
  • Gu, B., Zhang, W., Bendall, L., Chessell, I., Buell, G., Wiley, J. (2000). Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. American Journal of Physiology: Cell Physiology. 279 (4) , C1189-C1197.
  • Saad, S., Bendall, L., James, A., Gottlieb, D., Bradstock, K. (2000). Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts. Breast Cancer Research and Treatment. 63 (2) , 105-115.