Baharlou H, Canete N, Vine E, Hu K, Yuan Di, Sandgren KJ, Bertram KM,
Nasr N, Rhodes JW, Gosselink MP, Di Re A, Reza F, Ctercteko G, Pathma-Nathan N, Collins G, Toh J, Patrick E, Haniffa MA, Estes JD, Byrne SN, Cunningham AL, Harman AN. in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission.
Cell Reports 2022 – Accepted
York J, Gowrishankar K, Micklethwaite K, Palmer S, Cunningham A, Nasr N. strategies to eliminate the CD4 T cells HIV viral reservoir via CAR T cell immunotherapy. Frontiers Immunol 2022 – PMID:35572509
Duette G, Hiener B, Morgan H, Mazur F, Horsburgh BA, Fisher K, Tong O, Lee E, Ahn H, Shaik A, Fromentin R, Hoh R, Bacchus-Souffan C,
Nasr N, Cunningham A, Hunt P, Chomont N, Deeks SG, Kelleher AD, Schlub TE, Palmer S. The HIV-1 proviral landscape reveals
nef contributes to HIV-1 persistence in effector memory CD4+ T cells in individuals on long-term antiretroviral therapy.
J Clin Invest 2022– PMID:35133986
O’Neil TR, Hu K, Truong N, Arshad S, Shacklett BL, Cunningham AL and
Nasr N. The role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection.
Viruses 2021 – PMID:
33668777
Tong O, Duette G, Popovic N, O’Neil TR, Johnson B, Rana H, Royle C, Brouwer MAE, Baharlou H, Patrick E, Ctercteko G, Hunter E, Harman AN, Cunningham AL, and
Nasr N. Plasmacytoid Dendritic Cells Have Divergent Effects on HIV Infection of Initial Target Cells and Induce a Pro-retention Phenotype.
PLoS Pathogen 2021 – PMID: 33872331
Rhodes J, Botting RA, Bertram K, Rana H, Baharlou H, Longmuir-Vine EE, Vegh P, Fletcher J, O’Neil TR, Parnell GP, Graham JD,
Nasr N, Lim JJK, Barnouti L, Haertsch P, Gosselink MP, Di Re A, Ctercteko G, Jenkins GJ, Brooks AJ, Wines M, Patrick E, Byrne SN, Haniffa MA, Cunningham AL and Harman AN. Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues.
Nature Comms 2021 – PMID: 33846309
Bertram K, Tong O, Royle C, Turville S,
Nasr N, Cunningham T, Harman A. Manipulation of mononuclear phagocytes by HIV: Implications for early transmission events.
Frontiers Immunol 2019 –PMID: 31616434
Bertram K, Botting R, Baharlou, Rhodes JW, Rana H, Graham JD, Patrick E, Fletcher J, Plasto TM, Truong NR, Royle C, Doyle C, Tong O,
Nasr N, Barnouti L, Kohout M, Brooks AJ, Wines MP, Haertsch P, Lim J, Gosselink MP, Ctercteko G, Estes JD, Churchill MJ, Cameron PU, Hunter E, Haniffa, Cunningham AL, Harman AN. Identification of HIV Transmitting CD11c
+ Human Epidermal Dendritic Cells.
Nature Comms 2019 – PIMD: 31227717
Nasr N, Alshehri A, Wright TK, Shahid M, Heiner BM, Botting R, Harman AN, Helbig K, Kelleher AD, Suzuki, Hertzog P, Cunningham AL. Mechanism of Interferon Stimulated Gene Induction in HIV-1 Infected Macrophages in the Absence of Interferon Production.
J Virol 2017 – PIMD: 28768867.
Botting RA, Rana H, Bertram KM, Rhodes JW, Baharlou H,
Nasr N, Cunningham AL, Harman AN. Langerhans cells and sexual transmission of HIV and HSV. Rev Med Virol.
2017 – PIMD: 28044388
Ng W C, Londrigan S L,
Nasr N, Cunningham AL, Brooks AG, and Reading PC. The C-type lectin langerin functions a true receptor uptake and infectious entry of influenza A virus.
J Virol 2016 – PMID: 26468543.
Harman AN*,
Nasr N*, Feetham A, Galoyan A, Alshehri AA, Rambukwelle D, Botting RA, Hiener BM, Diefenbach E, Diefenbach RJ, Kim M, Mansell A, Cunningham AL. HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1.
J Virol 2015 – PMID: 25855743
* Equal First.
Kim N, Truong NR, James V, Bosnjak L, Sandgren KJ, Harman AN,
Nasr N, Bertram KM, Olbourne N, McKinnon K, Cohen RC; Cunningham AL. Relay of herpes simplex virus between langerhans cells and dermal dendritic cells in human skin.
Plos Path 2015 – PMID:25875649.
Marsden V, Donaghy H, Bertram K, Harman A,
Nasr N, Keoshkerian E, Merten S, Lloyd A, Cunningham AL. HSV-2 infected dendritic cells produce TNFα which enhances CCR5 expression and stimulates HIV production from adjacent infected cells.
J Immunol 2015 – PMID: 25840914.
Nasr N, Lai J, Botting RA, Mercier SK, Harman AN, Kim M, Turville SG, Center RJ, Domagala T, Gorry PR, Olbourne N, Cunningham AL. Inhibition of two temporal phases of HIV-1 transfer from primary langerhans cells to T cells: the role of langerin.
J Immunol 2014 – PMID: 25070850.
Nasr N, Harman A, Turville S, Cunningham AL. HIV infection of dendritic cells.
Methods Mol Biol 2014 – PMID: 24158826
Mercier SK, Donaghy H, Botting R, Turville SG, Harman AN,
Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson RJ, Moritz RL, Cunningham AL. The microvesicle component of HIV-1 inocula modulates dendritic cell infection, maturation, and enhances adhesion to and activation of T-lymphocytes.
Plos Path. 2013 – PMID: 24204260.
Harman AN, Bye CR,
Nasr N, Sandgren KJ, Kim M, Mercier SK, Botting RA, Lewin SR, Cunningham AL, Cameron PU. Identification of lineage relationships and novel markers of blood and skin human dendritic cells.
J Immunol 2013 – PMID:23183897.
Harman A, Kim M,
Nasr N, Cameron PU. Tissue dendritic cells as portals for HIV entry.
Reviews Med Virol 2013 – PMID: 23908074.
Cunningham AL, Harman N,
Nasr N. Initial HIV mucosal infection and dendritic cells.
EMBO Mol Med 2013 – PMID:23653303.
Cunningham AL, Harman AN, Kim M,
Nasr N, Lai J. Immunobiology of dendritic cells and the influence of HIV infection.
Adv Exp Med Biol 2013 – PMID:22975870.
Nasr N, Maddocks S, Turville SG, Harman AN, Woolger N, Helbig KJ, Wilkinson J, Bye CR, Wright TK, Rambukwelle D, Donaghy H, Beard MR, Cunningham AL. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Blood 2012 – PMID:22677126.
Harman AN, Lai J, Turville SG,
Samarajiwa S,
Gray L,
Marsden V,
Mercier S,
Jones K,
Nasr N, Cumming H,
Donaghy H,
Mak J,
Churchill M,
Hertzog P, Cunningham AL. HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production.
Blood 2011 – PMID: 21411754.
Huch JH, Cunningham AL, Arvin AM,
Nasr N, Santegoets SJ, Slobedman E, Slobedman B, Abendroth A. Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection.
J Virol 2010 – PMID:20130046.
Cunningham AL, Abendroth A, Jones C,
Nasr N, Turville S. Viruses, and Langerhans cells.
Immunol Cell Biol. 2010 – PMID:20445632.
Harman AN, Kraus M, Bye CR, Byth K, Turville SG, Tang O, Mercier SK,
Nasr N, Stern JL, Slobedman B, Driessen C, Cunningham AL. HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase.
Blood 2009 – PMID:19436054.
Gray L, Sterjovski J, Churchill M, Ellery P,
Nasr N, Lewin SR, Crowe SM, Wesselingh SL, Cunningham AL, Gorry PR. Uncoupling coreceptor usage of HIV-1 from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolate from patients with acquired immunodeficiency syndrome.
Virol 2005 – PMID:15916792.
Ewart G D,
Nasr N, Naif H, CoxGB, Cunningham AL, Gage PW. Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.
Antimicrob Agent and Chemother 2004 – PMID:15155246.
Qi Cheng J, Stevens RL, Wadley R, Collins A, Cooley M, Naif H,
Nasr N, Cunningham A, Katsoulotos G, Wanigasek Y, Roufogalis B, Krilis SA. IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1.
J Immunol 2002 – PMID:11937573.
Naif H., Cunningham AL, Alali M, Li S,
Nasr N, Buhler M, Schols D, de Clercq E, Stewart G. A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5-D32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.
J Virol 2002 – PMID:11884536.
Grant R, Naif H, Thuruthyil SJ,
Nasr N, Takikawa O, Kapoor V. Induction of indolamine 2,3-dioxygenase in primary human macrophages is strain dependent.
J Virol 2000 – PMID:10756023
.
Grant RS, Naif H, Thuruthyil SJ,
Nasr N, Littlejohn T, Takikawa O, Kapoor V. Induction of indolamine 2,3-dioxygenase in primary human macrophages by HIV-1.
Redox Report 2000 – PMID:10939284.