Lee K, Chan JY, Liang C, Ip CK, Shi YC, Herzog H, Hughes WE, Bensellam M, Delghingaro-Augusto V, Koina ME, Nolan CJ, Laybutt DR. XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice. Diabetologia 65(6):984-996, 2022
Nazari M, Ho KW, Langley N, Cha KM, Kodsi R, Wang M, Laybutt DR, Cheng K, Stokes RA, Swarbrick MM, Gunton JE. Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity. Sci Rep. 12(1):776, 2022
Kim JH, Delghingaro-Augusto V, Chan JY, Laybutt DR, Proietto J, Nolan CJ. The role of fatty acid signaling in islet beta-cell adaptation to normal pregnancy. Front. Endocrinol. 12:799081, 2022
Rajapaksha IG, Gunarathne LS, Asadi K, Laybutt R, Andrikopoulous S, Alexander IE, Watt MJ, Angus PW, Herath CB. Angiotensin Converting Enzyme-2 therapy improves liver fibrosis and glycemic control in diabetic mice with fatty liver. Hepatol Commun. 6(5):1056-1072, 2022
Yang CH, Ann-Onda D, Lin X, Fynch S, Nadarajah S, Pappas EG, Liu X, Scott JW, Oakhill JS, Galic S, Shi Y, Moreno-Asso A, Smith C, Loudovaris T, Levinger I, Eizirik DL, Laybutt DR, Herzog H, Thomas HE, Loh K. Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes. Mol Metab. 55:101413, 2022
Yu J, Laybutt DR, Kim LJ, Quek LE, Wu LE, Morris MJ, Youngson NA. Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide. Am J Physiol Endocrinol Metab. 321(1):E176-E189, 2021
Dhounchak S, Popp SK, Brown DJ, Laybutt DR, Biden TJ, Bornstein SR, Parish CR, Simeonovic CJ. Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes. PLoS One. 16(6):e0252607, 2021
Chan JY, Bensellam M, Lin RCY, Liang C, Lee K, Jonas JC, Laybutt DR. Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure. FASEB J. 35(6):e21608, 2021
Yan C, Zeng T, Lee K, Nobis M, Loh K, Gou L, Xia Z, Gao Z, Bensellam M, Hughes W, Lau J, Zhang L, Ip CK, Enriquez R, Gao H, Wang QP, Wu Q, Haigh JJ, Laybutt DR, Timpson P, Herzog H, Shi YC. Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. Nat Commun. 12(1):2622, 2021
Bensellam M, Laybutt DR, Jonas JC. Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response. Biology (Basel). 10(3):176, 2021
Yau B, Hays L, Liang C, Laybutt DR, Thomas HE, Gunton JE, Williams L, Hawthorne WJ, Thorn P, Rhodes CJ, Kebede MA. A fluorescent timer reporter enables sorting of insulin secretory granules by age. J Biol Chem. 295(27):8901-8911, 2020
Stratakis CA, Laybutt DR, Laudet V, Klinge CM. Epidemics will always come (and go): The need to prepare for the next one, research on COVID-19, and the role of molecular and cellular endocrinology. Mol Cell Endocrinol. 511:110863, 2020
Guay C, Abdulkarim B, Tan JY, Dubuis G, Rütti S, Laybutt DR, Widmann C, Regazzi R, Marques AC. Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion. Sci Rep. 10(1):6413, 2020
Bensellam M, Chan JY, Lee K, Joglekar MV, Hardikar AA, Loudovaris T, Thomas HE, Jonas JC, Laybutt DR. Phlda3 regulates beta cell survival during stress. Sci Rep. 9(1): 12827, 2019
Bensellam M, Shi YC, Chan JY, Laybutt DR, Chae H, Abou-Samra M, Pappas EG, Thomas HE, Gilon P, Jonas JC. Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta-cell compensation and failure. Diabetologia. 62(12):2273-2286, 2019
Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE. β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes. Cell Rep. 27(8):2370-2384.e6, 2019
Chan JY, Lee K, Maxwell EL, Liang C, Laybutt DR. Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes. Diabetologia. 62(6):993-999, 2019
Macdonald GC, Hesselson SE, Chan JY, Jenkins AB, Laybutt DR, Hesselson D, Campbell LV. Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus. Diabetes Res Clin Pract. 148:64-71, 2019
Loh K, Shi YC, Bensellam M, Lee K, Laybutt DR, Herzog H. Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism. Sci Rep. 8(1):11835, 2018
Sanchez-Parra C, Jacovetti C, Dumortier O, Lee K, Peyot ML, Guay C, Prentki M, Laybutt DR, Van Obberghen E, Regazzi R. Contribution of the long non-coding RNA H19 to neonatal and adult rodent β-cell mass expansion. Diabetes. 67(11):2254-2267, 2018
Lee NJ, Ali N, Zhang L, Qi Y, Clarke I, Enriquez RF, Brzozowska M, Lee IC, Rogers MJ, Laybutt DR, Center JR, Baldock PA, Herzog H. Osteoglycin, a novel coordinator of bone and glucose homeostasis. Mol Metab. 13:30-44, 2018
Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC. On-target action of anti-tropomyosin drugs regulates glucose metabolism. Sci Rep. 15;8(1):4604, 2018
Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA. Evidence against a role for NLRP3-driven islet inflammation in db/db mice. Mol Metab. 10:66-73, 2018
Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R. Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Mol Metab. 9:69-83, 2018
Bensellam M, Jonas JC, Laybutt DR. Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions. J Endocrinol. 236(2):R109-R143, 2018
Motterle A, Gattesco S, Peyot ML, Esguerra JLS, Gomez-Ruiz A, Laybutt DR, Gilon P, Burdet F, Ibberson M, Eliasson L, Prentki M, Regazzi R. Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes. Mol Metab. 6(11):1407-1418, 2017
Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 8(1):490, 2017
Minard AY, Wong MK, Chaudhuri R, Tan SX, Humphrey SJ, Parker BL, Yang JY, Laybutt DR, Cooney GJ, Coster AC, Stöckli J, James DE. Hyperactivation of the insulin signaling pathway improves intracellular proteostasis by coordinately up-regulating the proteostatic machinery in adipocytes. J Biol Chem. 291(49):25629-25640, 2016
Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet. 48(5):519-27, 2016
Herbert TP, Laybutt DR. A re-evaluation of the role of the unfolded protein response in islet dysfunction: maladaptation or a failure to adapt? Diabetes. 65(6):1472-80, 2016
Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in type 2 diabetes. PLoS Genet. 12(5): e1006033, 2016
Bensellam M, Maxwell EL, Chan JY, Luzuriaga J, West PK, Jonas JC, Gunton JE, Laybutt DR. Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells. Diabetologia. 59(7):1492-502, 2016
Chan JY, Luzuriaga J, Maxwell EL, West PK, Bensellam M, Laybutt DR. The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK. Mol Cell Endocrinol. 413:189-201, 2015
Shi YC, Loh K, Bensellam M, Lee K, Zhai L, Lau J, Cantley J, Luzuriaga J, Laybutt DR, Herzog H. Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in female mice. Endocrinology. 156(9):3122-36, 2015
Pinho AV, Bensellam M, Wauters E, Rees M, Giry-Laterriere M, Mawson A, Ly le Q, Biankin AV, Wu J, Laybutt DR, Rooman I. Pancreas-specific Sirt1-deficiency in mice compromises beta-cell function without development of hyperglycemia. PLoS One. 10(6):e0128012, 2015
Jacovetti C, Jimenez V, Ayuso E, Laybutt R, Peyot ML, Prentki M, Bosch F, Regazzi R. Contribution of intronic miR-338-3p and its hosting gene AATK to compensatory β-Cell mass expansion. Mol Endocrinol. 29(5):693-702, 2015
Bensellam M, Montgomery MK, Luzuriaga J, Chan JY, Laybutt DR. Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells. Diabetologia. 58(4):758-70, 2015
Lee NJ, Nguyen AD, Enriquez RF, Luzuriaga J, Bensellam M, Laybutt R, Baldock PA, Herzog H. NPY signalling in early osteoblasts controls glucose homeostasis. Mol Metab. 4(3):164-74, 2015
Walters SN, Luzuriaga J, Chan JY, Grey ST, Laybutt DR. Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets. J Mol Endocrinol. 51(2):225-32, 2013
Nesca V, Guay C, Jacovetti C, Menoud V, Peyot ML, Laybutt DR, Prentki M, Regazzi R. Identification of particular groups of microRNAs that positively or negatively impact beta cell function in obese models of type 2 diabetes. Diabetologia. 56(10):2203-12, 2013
Chan JY, Luzuriaga J, Bensellam M, Biden TJ, Laybutt DR. Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes. Diabetes. 62(5):1557-68, 2013
Kang ZF, Deng Y, Zhou Y, Fan RR, Chan JC, Laybutt DR, Luzuriaga J, Xu G. Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signaling in the beta cell in mouse models of diabetes. Diabetologia. 56(2):423-33, 2013
Jacovetti C, Abderrahmani A, Parnaud G, Jonas JC, Peyot ML, Cornu M, Laybutt R, Meugnier E, Rome S, Thorens B, Prentki M, Bosco D, Regazzi R. MicroRNAs contribute to compensatory b cell expansion during pregnancy and obesity. J Clin Invest. 122(10):3541-51, 2012
Bensellam M, Laybutt DR, Jonas JC. The molecular mechanisms of pancreatic b-cell glucotoxicity: Recent findings and future research directions. Mol Cell Endocrinol. 364(1-2):1-27, 2012
Chan JY, Biden TJ, Laybutt DR. Cross-talk between the unfolded protein response and nuclear factor-kB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets. Diabetologia. 55:2999-3009, 2012
Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. PLoS One. 7(6):e39462, 2012
Achard CS, Laybutt DR. Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance. Endocrinology. 153(5): 2164-77, 2012
Ren LP, Chan SMH, Zeng XY, Laybutt DR, Iseli TJ, Sun RQ, Kraegen EW, Cooney GJ, Turner N Ye JM. Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance. PLoS One. 7(2):e30816, 2012
Bensellam M, Duvillié B, Rybachuk G, Laybutt DR, Magnan C, Guiot Y, Pouysségur J, Jonas JC. Glucose-induced O2 consumption activates Hypoxia Inducible Factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One. 7(1):e29807, 2012
Åkerfeldt MC, Laybutt DR. Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes 60(10):2506-14, 2011
Chan JY, Cooney GJ, Biden TJ, Laybutt DR. Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia. 54(7):1766-76, 2011
Boslem E, Macintosh G, Preston AM, Bartley C, Busch AK, Fuller M, Laybutt DR, Meikle PJ, Biden TJ. A lipidomic screen of palmitate-treated MIN6 b-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Biochem J. 435(1):267-76, 2011
Cantley J, Boslem E, Laybutt DR, Cordery DV, Pearson G, Carpenter L, Leitges M, Biden TJ. Deletion of protein kinase C delta modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. Diabetologia. 54(2):380-9, 2011
Gu X, Li K, Laybutt DR, He ML, Zhao HL, Chan JC, Xu G. Bip overexpression, but not CHOP inhibition, attenuates fatty acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells. Life Sciences. 87(23-26):724-32, 2010
Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring. Nature. 467(7318):963-6, 2010
Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang X, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Hypoxia-inducible factor-1 alpha regulates beta-cell function in mice and in human islets. J Clin Invest. 120(6):2171-83, 2010
Preston AM, Gurisik E, Bartley C, Laybutt DR, Biden TJ. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia. 52(1): 2369-73, 2009
Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 23(8):1281-90, 2009
Kebede M, Favaloro J, Gunton JE, Laybutt DR, Shaw ML, Wong N, Fam BC, Aston-Mourney K, Rantzau C, Zulli A, Proietto J, Andrikopoulos S. Fructose-1,6-bisphosphatase overexpression in pancreatic b-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function. Diabetes. 57:1887-95, 2008
Åkerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR. Cytokine-induced β-cell death is independent of endoplasmic reticulum stress signalling. Diabetes. 57:3034-44, 2008
Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R. Alterations in microRNA expression contribute to fatty acid-induced pancreatic -cell dysfunction. Diabetes. 57:2728-36, 2008
Laybutt DR, Preston AM, Åkerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. 50: 752-63, 2007
Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 56:1551-8, 2007
Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation. Diabetologia. 50:2117-25, 2007
Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ. Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab.. 6:320-8, 2007
Molero JC, Waring SG, Cooper A, Turner N, Laybutt R, Cooney GJ and James DE. Casitas b-lineage lymphoma deficient mice are protected against high-fat diet-induced obesity and insulin resistance. Diabetes. 55:708-15, 2006
Zraika S, Aston-Mourney K, Laybutt DR, Kebede M, Dunlop ME, Proietto J, Andrikopoulos S. The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets. Diabetologia. 49:1254-63, 2006
Boey D, Heilbronn L, Sainsbury A, Laybutt R, Kriketos A, Herzog H, Campbell LV. Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes. Neuropeptides. 40:317-24, 2006
Kjørholt C, Åkerfeldt MC, Biden TJ, Laybutt DR. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of b-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes. 54:2755-63, 2005
Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ. Increased fatty acid desaturation and enhanced expression of stearoyl CoA desaturase protects pancreatic b-cells from lipoapoptosis. Diabetes. 54:2917-24, 2005
Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC. Critical reduction in beta-cell mass results in two distinct outcomes over time: adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem. 278: 2997-3005, 2003
Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-weir S, Weir GC. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 277:12998-3006, 2002
Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas J-C, Groff A, Ferran F, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. 51: 413-23, 2002
Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in b-cells disrupted by hyperglycemia. J Biol Chem. 277:10912-21, 2002
Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression and diabetes. Diabetes. 51:1793-804, 2002