Tackling Crohn’s Disease
This project will compare the immune cells in healthy tissue with those affected by ulcerative colitis and Crohn’s disease. In so doing, we aim to discover new targets for therapy. Our studies will initially focus on those immune cells most likely to play a role in regulating immune tolerance including mononuclear phagocytes (dendritic cells and macrophages), innate lymphoid cells, B and T lymphocytes and MAIT cells. To interrogate these immune cells, we will use a range of cutting edge technologies including multi-parameter flow and mass cytometry, immunofluorescence microscopy and ‘Hyperion’. Ultimately, understanding how the immune composition differs in diseased tissues will provide clues about the mechanism underlying these diseases and pave the way for therapeutic strategies to treat or cure ulcerative colitis and Crohn’s disease.