Our group’s main research interest revolves around deciphering the functional role of viral proteins in various stages of viral replication including entry, transport, assembly, and egress.
We are investigating the interactions between host molecular motor proteins and viral proteins from HSV-1. These interactions mediate the transport of viral particles up and down the axons of nerve cells, a key phase of the lifecycle of HSV-1.
We are also investigating the role of structural viral proteins in the assembly of HSV-1 and how such viral proteins engage the host cell during all stages of the viral replication cycle. This knowledge will enhance the understanding of the mechanism of HSV-1 replication in human cells and provide insights into the host cell processes hijacked by HSV-1. Ultimately this will provide new targets for the development of more effective antivirals and facilitate the tailoring of HSV-1 for use in oncolytic virotherapy.