Preclinical Research in PKD

  • Cyclin Dependent Kinases As Drug-Targets To Reduce Renal Cyst Formation and Scarring in Polycystic Kidney Disease
  • Vitamin D3 receptor signalling to prevent kidney failure due to polycystic kidney disease
  • NF-kappaB as a therapeutic target in polycystic kidney disease

Clinical Research in PKD

  • Controlled trial of slowing kidney disease progression from the inhibition of xanthine oxidase (CKD-FIX) (funded by NHMRC)
  • Randomised controlled trial to determine the safety and efficacy of prescribed water intake to prevent kidney failure due to ADPKD (PREVENT-ADPKD)  
  • Multi-centre, open-label, extension study to evaluate the long-term efficacy and safety of oral tolvaptan tablet regimens in subjects with ADPKD (REPRISE/TEMPO) (Otsuka)