Muscle wasting and weakness are common, and associate with an increased risk of death. Therapies to improve muscle funcation are very limited, and understanding of the transcriptional control for myocyte development and function is limited. This project will work with transcription factor vitamin D receptor and its role in myocyte and satellite cell (muse stem cell) development.
This project will involve oppotunities to work with novel genetically modified mice, TRAP (translating ribosome affinity purification), RNA-srequencing, histology, muscle fibre typing and some human smaples to study the role of Vitamin D, its analodues and the vitamin D receptor in muscle function.
Supervisor: Professor Jenny Gunton firstname.lastname@example.org