PhD, Masters, Honours or Summer Students
We showed that C. neoformans (Cn) activiates its PHO signaling pathway to acquire phosphate from the human host and to tolerate the immune system. We also showed that blocking the PHO pathway prevents Cn infection of the brain (meningitis) in a mouse model. This project will identify key components in the PHO pathway that may be suitable as novel antifungal drug targets.
Supervisor: Associate Professor Julie Djordjevic - email@example.com