Obesity occurs when energy intake exceeds energy expenditure. Current treatments for obesity are largely ineffective, and two-thirs of Australian adults are now overweight or obese.

The aim of this project is to investigate agents which may increase browning or beiging of human fat. The project will determine the whole-body effects of browning agents on energy and glucose and fast handling (metabolism) in mice which have receive human fat transplants. These experiments will involve pharmacological treatment of mice, measurement of glucose/lipid metabolism, measurement of energy metabolism at the whole-body and tissue levels. We will also be using lentivirally-delivered shRNA to silence the expression of genes in adipocytes and adipose tissue.

Supervisors: Professor Jenny Gunton -