Publications

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2016
  • Mills, K., Brocardo, M., Henderson, B. (2016). APC binds the miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Molecular Biology of the Cell. 27 (3) , 466-482. [More Information]
  • Lui, C., Ashton, C., Sharma, M., Brocardo, M., Henderson, B. (2016). APC functions at the centrosome to stimulate microtubule growth. The International Journal of Biochemistry and Cell Biology. 70 , 39-47. [More Information]
  • Marzec, K., Martino-Echarri, E., Irminger-Finger, I., Henderson, B. (2016). BARD1 splice variants display mislocalization in breast cancer cells and can alter the apoptotic response to cisplatin. Cancer Letters. 381 (1) , 149-155. [More Information]

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  • Jamieson, C., Mills, K., Lui, C., Semaan, C., Molloy, M., Sharma, M., Forwood, J., Henderson, B. (2016). Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells. Experimental Cell Research. 341 (2) , 196-206. [More Information]
  • Lui, C., Mok, M., Henderson, B. (2016). Characterization of adenomatous polyposis coli protein dynamics and localization at the centrosome. Cancers. 8 (5) , 1-15. [More Information]
  • Sharma, M., Jamieson, C., Lui, C., Henderson, B. (2016). Distinct hydrophobic "patches" in the N- and C-tails of beta-catenin contribute to nuclear transport. Experimental Cell Research. 348 (2) , 132-145. [More Information]
  • Martino-Echarri, E., Brocardo, M., Mills, K., Henderson, B. (2016). Tankyrase inhibitors stimulate the ability of tankyrases to bind axin and drive assembly of β-catenin degradation-competent axin puncta. PloS One. 11 (3) , 1-19. [More Information]

2015
  • Lei, Y., Henderson, B., Emmanuel, C., Harnett, P., deFazio, A. (2015). Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncogene. 34 (4) , 485-495. [More Information]
  • Jamieson, C., Lui, C., Brocardo, M., Martino-Echarri, E., Henderson, B. (2015). Rac1 augments Wnt signaling by stimulating Beta-catenin-lymphoid enhancer factor-1 complex assembly independent of Beta-catenin nuclear import. Journal of Cell Science. 128 (21) , 3933-3946. [More Information]
  • Tembe, V., Martino-Echarri, E., Marzec, K., Mok, M., Brodie, K., Mills, K., Lei, Y., deFazio, A., Rizos, H., Kettle, E., Henderson, B., et al (2015). The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cellular Signalling. 27 (9) , 1763-1771. [More Information]

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  • Hedgepeth, S., Garcia, M., Wagner II, L., Rodriguez, A., Chintapalli, S., Snyder, R., Hankins, G., Henderson, B., Brodie, K., Yule, D., et al (2015). The BRCA1 tumor suppressor binds to inositol 1,4,5 trisphosphate receptors to stimulate apoptotic calcium release. The Journal of Biological Chemistry. 290 (11) , 7304-7313. [More Information]

2014
  • Martino-Echarri, E., Henderson, B., Brocardo, M. (2014). Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget. 5 (20) , 9889-9990.
  • Jamieson, C., Sharma, M., Henderson, B. (2014). Targeting the β-catenin nuclear transport pathway in cancer. Seminars in Cancer Biology. 27 , 20-29. [More Information]
  • Mok, M., Cheng, A., Henderson, B. (2014). The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells. The International Journal of Biochemistry and Cell Biology. 57 , 27-34. [More Information]

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  • Sharma, M., Johnson, M., Brocardo, M., Jamieson, C., Henderson, B. (2014). Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer. Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes. Advances in Experimental Medicine and Biology 773 , 353-372.

2013
  • Johnson, M., Sharma, M., Mok, M., Henderson, B. (2013). Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1833 (10) , 2334-2347. [More Information]

2012
  • Mok, M., Henderson, B. (2012). A two-step fluorescence-activated cell sorting approach to isolate genetically modified mammalian cells with isopropyl-beta-D-thiogalactoside (IPTG)-inducible gene expression. Cytometry Part A. 81A (2) , 101-104. [More Information]
  • Lui, C., Mills, K., Brocardo, M., Sharma, M., Henderson, B. (2012). APC as a Mobile Scaffold: Regulation and Function at the Nucleus, Centrosomes, and Mitochondria. IUBMB Life. 64 (3) , 209-214. [More Information]
  • Brodie, K., Mok, M., Henderson, B. (2012). Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation. Cellular Signalling. 24 (2) , 451-459. [More Information]

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  • Brodie, K., Henderson, B. (2012). Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome: a Role for the Nuclear Export Signal, CRM1, and Aurora A Kinase. Journal of Biological Chemistry. 287 (10) , 7701-7716. [More Information]
  • Brodie, K., Henderson, B. (2012). Regulation of BRCA1/BARD1 dynamics and function at the centrosome. ComBio2012. , SYM-21-01.
  • Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry. 287 (2) , 819-831. [More Information]
  • Mok, M., Henderson, B. (2012). The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. The International Journal of Biochemistry and Cell Biology. 44 (9) , 1398-1409. [More Information]
  • Mok, M., Henderson, B. (2012). The In Vivo Dynamic Organization of BRCA1-A Complex Proteins at DNA Damage-Induced Nuclear Foci. Traffic (Malden). 13 (6) , 800-814. [More Information]
  • Johnson, M., Henderson, B. (2012). The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation.. Bioarchitecture. 2 (4) , 138-142. [More Information]
  • Mok, M., Henderson, B. (2012). Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci. Radiotherapy and Oncology. 103 (3) , 415-420. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2012). Wnt signaling from membrane to nucleus: β-catenin caught in a loop. The International Journal of Biochemistry and Cell Biology. 44 (6) , 847-850. [More Information]

2011
  • Brocardo, M., Borowiec, J., Henderson, B. (2011). Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. The International Journal of Biochemistry and Cell Biology. 43 (9) , 1354-1364. [More Information]
  • Johnson, M., Sharma, M., Brocardo, M., Henderson, B. (2011). IQGAP1 Translocates to the Nucleus in Early S-Phase and Contributes to Cell Cycle Progression After DNA Replication Arrest. The International Journal of Biochemistry and Cell Biology. 43 (1) , 65-73. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2011). Regulation of β-Catenin Nuclear Dynamics by GSK-3β Involves a LEF-1 Positive Feedback Loop. Traffic (Malden). 12 (8) , 983-999. [More Information]

2010
  • Mok, M., Henderson, B. (2010). A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci.. Cellular Signalling. 22 (1) , 47-56. [More Information]
  • Henderson, B. (2010). Cryptic mitochondrial targeting signals in human ARF: Clues to controlling cancer?. Cell Cycle. 9 (5) , 866-867.
  • Brodie, K., Henderson, B. (2010). Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cellular Signalling. 22 (2) , 291-302. [More Information]

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  • Sharma, M., Henderson, B. (2010). Methods to Measure Nuclear Export of Beta-Catenin Using Fixed and Live Cell Assays. Transcription Factors: Methods and Protocols - Methods in Molecular Biology Volume 647. 647 , 187-197.
  • Flegg, C., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M., Mills, K., Henderson, B. (2010). Nuclear Export and Centrosome Targeting of the Protein Phosphatase 2A Subunit B56alpha: Role of B56alpha in Nuclear Export of the Catalytic Subunit. Journal of Biological Chemistry. 285 (24) , 18144-18154. [More Information]
  • Henderson, B., Brocardo, M., Medina-Palazon, C. (2010). Regulated Trafficking of the APC tumour suppressor to mitochondria, nucleus, centosomes and beyond. Ozbio - Protein trafficking session. , SYM-50-03.
  • Henderson, B. (2010). Regulation of BRCA1 dynamics and breast cancer. 3rd China-University of Sydney Symposium and University Expo.
  • Henderson, B. (2010). Regulation of BRCA1 in breast cancer. 3rd Annual World Cancer Congress, Breast Cancer Conference.

2009
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology. 175 (2) , 580-591. [More Information]
  • Johnson, M., Sharma, M., Henderson, B. (2009). IQGAP1 regulation and roles in cancer. Cellular Signalling.
  • Manniccia, A., Lewis, C., Begum, N., Xu, J., Cui, J., Chipitsyna, G., Aysola, K., Reddy, V., Bhat, G., Fujimura, Y., Henderson, B., et al (2009). Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. Journal of Cellular Physiology. 219 (3) , 634-641. [More Information]

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  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling. 21 (2) , 339-348. [More Information]

2008
  • Brocardo, M., Henderson, B. (2008). APC shuttling to the membrane, nucleus and beyond. Trends in Cell Biology. 18 (12) , 587-596. [More Information]
  • Chircop (nee Fabbro), M., Henderson, B. (2008). BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters. Cancer Letters. 263 (2) , 189-196. [More Information]
  • Henderson, B. (2008). BRCA1 redistribution in response to DNA damage. 4th Australian Health and Medical Research Congress (AHMRC).

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  • Brocardo, M., Henderson, B. (2008). Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells. Methods in Molecular Biology 468: Wnt Signaling, Volume 1: Pathway Methods and Mammalian Models. 1 , 77-89.
  • Brocardo, M., Lei, Y., Tighe, A., Taylor, S., Mok, M., Henderson, B. (2008). Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival. Journal of Biological Chemistry. 283 (9) , 5950-5959. [More Information]
  • Henderson, B. (2008). Movement of tumour suppressor proteins to mitochondria. AussieMit, Mitochondrial Research conference.

2007
  • Zanella, F., Rosado, A., Blanco, F., Henderson, B., Carnero, A., Link, W. (2007). An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays. ASSAY and Drug Development Technologies. 5 (3) , 333-341.
  • Tembe, V., Henderson, B. (2007). BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and Apoptosis. Journal of Biological Chemistry. 282 (28) , 20513-20522.
  • Bolli, N., Nicoletti, I., De Marco, M., Bigerna, B., Pucciarini, A., Mannucci, R., Martelli, M., Liso, A., Mecucci, C., Fabbiano, F., Henderson, B., et al (2007). Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Research. 67 (13) , 6230-6237.

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  • Lovelock, P., Spurdle, A., Mok, M., Farrugia, D., Lakhani, S., Healey, S., Arnold, S., Buchanan, D., kConFab Investigators, .., Couch, F., Henderson, B., et al (2007). Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?. Breast Cancer Research. 9 (6) , 1-13.
  • Au, W., Henderson, B. (2007). Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cellular Signalling. 19 (9) , 1879-1892. [More Information]
  • Sharma, M., Henderson, B. (2007). IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. Journal of Biological Chemistry. 282 (11) , 8545-8556.
  • Tembe, V., Henderson, B. (2007). Protein trafficking in response to DNA damage. Cellular Signalling. 19 (6) , 1113-1120. [More Information]

2006
  • Lovelock, P., Healey, S., Au, W., Sum, E., Tesoriero, A., Wong, E., Hinson, S., Brinkworth, R., Bekessy, A., Diez, O., Henderson, B., et al (2006). Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants.. Journal of Medical Genetics. 43 (1) , 74-83.
  • Sharma, M., Leung, L., Brocardo, M., Henderson, J., Flegg, C., Henderson, B. (2006). Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin.. Journal of Biological Chemistry. 281 (25) , 17140-17149.

2005
  • Schüchner, S., Tembe, V., Rodriguez, J., Henderson, B. (2005). Nuclear targeting and cell cycle regulatory function of human BARD1.. Journal of Biological Chemistry. 280 (10) , 8855-8861.
  • Brocardo, M., Näthke, I., Henderson, B. (2005). Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.. EMBO Reports. 6 (2) , 184-90.
  • Henderson, B. (2005). Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.. BioEssays. 27 (9) , 884-893. [More Information]

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  • Au, W., Henderson, B. (2005). The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.. Journal of Biological Chemistry. 280 (8) , 6993-7001.

2004
  • Chircop (nee Fabbro), M., Schuechner, S., Au, W., Henderson, B. (2004). Bard1 Regulates Brca1 Apoptotic Function By A Mechanism Involving Nuclear Retention.. Experimental Cell Research. 298 (2) , 661-673.
  • Rodriguez, J., Au, W., Henderson, B. (2004). Cytoplasmic Mislocalization Of Brca1 Caused By Cancer-Associated Mutations In The Brct Domain.. Experimental Cell Research. 293 (1) , 14-21.
  • Rodriguez, J., Schuchner, S., Au, W., Chircop (nee Fabbro), M., Henderson, B. (2004). Nuclear-Cytoplasmic Shuttling Of Bard1 Contributes To Its Proapoptotic Activity And Is Regulated By Dimerization With Brca1.. Oncogene. 23 (10) , 1809-1820.

2003
  • Keough, R., Macmillan, E., Lutwyche, J., Gardner, J., Tavner, F., Jans, D., Henderson, B., Gonda, T. (2003). Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes crm1-dependent and independent nuclear export pathways. Experimental Cell Research. 289 (1) , 108-123.
  • Henderson, B. (2003). Nuclear transport as a target for cancer therapies. Drug Discovery Today. 8 (6) , 249.
  • Chircop (nee Fabbro), M., Henderson, B. (2003). Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Experimental Cell Research. 282 (2) , 59-69.

2002
  • Chircop (nee Fabbro), M., Rodriguez, J., Baer, R., Henderson, B. (2002). BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. Journal of Biological Chemistry. 277 (24) , 21315-21324.
  • Henderson, B., Galea, M., Schuechner, S., Leung, L. (2002). Lymphoid enhancer factor-1 blocks adenomators polyposis coli-mediated nuclear export and degradation of B-catenin. Journal of Biological Chemistry. 277 (27) , 24258-24264.
  • Henderson, B., Fagotto, F. (2002). The ins and outs of APC and B-catenin nuclear transport. EMBO Reports. 3 (9) , 834-839.

2001
  • Galea, M., Henderson, B., Eleftheriou, A. (2001). ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by B56a subunit of protein phosphatase 2A. Journal of Biological Chemistry. 276 , 45833-45839.
  • Lam, M., Henderson, B., Gillespie, M., Jans, D. (2001). Dynamics of Leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein. Traffic. 2 (11) , 812-819.
  • Lixin, R., Efthymiadis, A., Henderson, B., Jans, D. (2001). Novel properties of the nucleolar targeting signal of human angiogenin. Biochemical and Biophysical Research Communications. 284 (1) , 185-193.

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  • Eleftheriou, A., Yoshida,, M., Henderson, B. (2001). Nuclear Export of Human B-Catenin can occur independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppresor. Journal of Biological Chemistry. 276 (28) , 25883-25888.

2000
  • Henderson, B., Eleftheriou, A. (2000). A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Experimental Cell Research. 256 (1) , 213-224.
  • Rodriguez, J., Henderson, B. (2000). Identification of a functional nuclear export sequence in BRCA1. Journal of Biological Chemistry. 275 (49) , 38589-38596.